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Then they compared the frequency of serious digestive problems in those patients to the same set of problems in people taking a different type of medication for weight loss, bupropion-naltrexone, which is sold as pill called Contrave
Trivedi MH, Walker R, Ling W, et al

Some compartments deflate dramatically, while others are preserved

Others see only a small shift, especially if they are building muscle or if hormonal water retention is present