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Compounding this problem just because this is health care, and you compound every problem

adherence to a hypocaloric diet (less than 1000 kcal / day)

Combination therapy: Patients with type 2 diabetes mellitus to improve glycemic control in combination with sulfonylurea derivatives (triple combination: metformin + sitagliptin + sulfonylurea derivative) when diet and exercise regimen in combination with two of these three drugs (metformin, sitagliptin or sulfonylurea derivatives) are not lead to adequate glycemic control

Provide ways to lower medication costs Many patients have to take GLP-1s long-term, especially if they want sustained effects

However, larger clinical trials are still needed to confirm these positive results