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These benefits are not trivial

10.1016/j.peptides.2011.02.011 Peptides 159 TakedaJ.SeinoY.TanakaK.FukumotoH.KayanoT.TakahashiH.et al (1987)

Ajuste de los hipoglucemiantes concomitantes: Con respecto a los hipoglucemiantes concomitantes en pacientes con DM2, varios anlisis post hoc han demostrado que los efectos beneficiosos del AR GLP-1 son independientes de la metformina, el medicamento de primera lnea ms utilizado en este poblacin de pacientes

However, some known adverse events were increased in SGLT2 inhibitor treatment, such as genital infection, diabetic ketoacidosis, and volume depletion

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