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In a single series of 289 patients who developed recurrences after initial surgery, 16% died of cancer at a median time of 5 years after recurrence.[5] The prognosis for patients with clinically detectable recurrences is generally poor, regardless of cell type.[30] Patients with local or regional tumor recurrence detected only by 131I scan have a better prognosis.[31] The selection of further treatment depends on many factors, including: Cell type

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doi: 10.1007/s00125-007-0753-6