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Description
In a randomized, placebo-controlled study, pemvidutide, a dual GLP-1/GCG receptor agonist, significantly decreased liver fat content by up to 68.5% after 12 weeks of treatment, accompanied by reductions in hepatic inflammation markers and body weight, highlighting the potential of dual receptor agonists to modify MASLD pathophysiology (47)

Both Wegovy and Ozempic contain the GLP-1 agonist semaglutide, but Wegovy is prescribed for long-term weight management and certain forms of liver disease, while Ozempic is used to control blood sugar in type 2 diabetes and help protect the heart and kidneys
They focused on adults with type 2 diabetes who had started either GLP-1 receptor agonists or metformin as their initial diabetes therapy
Pederson RA, Satkunaraja M, McIntosh CH, Scrocchi LA, Flamenz D, Schuit F, Drucker DJ, Wheeler MB

doi: 10.2337/dc19-S009
