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Nat Med 28:303314

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Molecular weight confirmed at 4,731.33 g/mol via mass spectrometry

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CEE: conjugated equine estrogen CKD: chronic kidney disease CVD: cardiovascular diseases ERT: estrogen replacement therapy ET: estrogen-only therapy GLP-1: glucagon-like peptide 1 HbA1c: glycated hemoglobin HDL: high-density lipoprotein HOMA-IR: homeostatic model assessment for insulin resistance HRT: hormone replacement therapy LDL: low-density lipoprotein QoL: quality of life RCTs: randomized controlled trials SGLT2: sodium-glucose co-transporter 2 T2DM: type 2 diabetes mellitus VTE: venous thromboembolism WHI: Womens Health Initiative The authors thank Fatima M.A