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We also recently discovered that HFD impairs intestinal NAMPT-mediated NAD + biosynthesis and disrupts the Wnt signaling pathway, GLP-1 production, and whole-body glucose metabolism

11,242,243 Long-term human studies demonstrated that chronic DPP-IV inhibition did not significantly mediate any cardiovascular (CV) benefits

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That means it's a molecule engineered to bind to GLP-1 receptors and activate them not by entering through the digestive system, but by bypassing the gut entirely via injection

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