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Clinical Perspective The panel concluded that the benefits of GLP-1RAs far outweigh potential ocular risks, given their proven: ~11.5 % HbA1c reduction 515 % weight loss (SURPASS & STEP programs) ~1426 % relative risk reduction in major CV events Hence, appropriate screening, not avoidance, should guide practice

doi: 10.1038/s41591-022-01707-4 78 US National Institutes of Health

Permitted procedures included esophagogastroduodenoscopy (EGD), endoscopic ultrasonography (EUS), or endoscopic retrograde cholangiopancreatography (ERCP)

Metformin immediate-release is taken by mouth twice daily, while the extended-release formulation allows once-daily dosing

With less weight to carry, women with lipedema often experience improved mobility and reduced discomfort during physical activities