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There have also been documented local skin reactions when using GLP-1 RAs, particularly with the long-acting formulations
References Ahrn B (2015) Hepato-incretin function of GLP-1: novel concept and target in type 1 diabetes

Diabetologia 47: 18611872
Rise of Dual and Triple Agonists: Beyond GLP-1, newer drugs target GIP and glucagon receptors for enhanced efficacy (e.g., Tirzepatide, Retatrutide)

the current evidence for these interventions is still limited and larger trials are urgently needed
