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Both target the GLP-1 receptor

Phase 3 studies specifically targeting NASH as a primary indication are ongoing

Summary A targeted and individualized nutrition and physical activity regimen should be instituted for each patient with a focus on optimizing protein intake and performing frequent resistance training in order to minimize loss of muscle mass while promoting the loss of fat mass

Brief exposure to room temperature before opening is generally safe if it occurs during shipping or normal handling

Subsequently, semaglutide (SEMA), a once-weekly injectable GLP-1 receptor agonist, was launched in 2021.1,3 Structure and mechanism of action Both LIRA and SEMA are subcutaneously administered GLP-1 receptor agonists, sharing 97% and 94% homology, respectively, with the native GLP-1 molecule