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Amato et al 55 reported that GLP-1 receptor (GLP-1R) is expressed in the nitrergic neurons of the myenteric plexus in human colon circular muscular strips and, once activated by exogenous GLP-1, mediates an inhibitory effect on large intestinal motility through nitric oxide neural release resulting in reduction of the spontaneous contractile activity of the smooth muscles, which may contribute to delaying of intestinal propulsion to increase water and electrolyte absorption

Metformin is occasionally combined with GLP-1 agonists for additional metabolic benefits, particularly in individuals with insulin resistance or prediabetes

Zepbound is FDA-approved for chronic weight management, while Wegovy is approved for type 2 diabetes but shows even greater average weight loss in studies

M., & Ge, W