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[126] Boehringer Ingelheim's oral anti-diabetic Linagliptin, BI 1077, and two of Lilly's insulin analogs, LY2605541 and LY2963016, were in phase II and III of clinical development at that time

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In the small intestine, it increases the secretion of incretin hormones (like GLP-1) in response to nutrient ingestion

This manifests as hepatic injury and inflammation in the liver and can range from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH), also known as nonalcoholic steatohepatitis (NASH) (172, 173)