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evaluated 25 RCTs and observational studies of GLP-1 RA in patients with type 2 diabetes up to 2012

In cell based assays, increased cyclic AMP signaling has been linked to phosphorylation events that influence transcriptional regulators and metabolic enzymes

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10.1186/s13287-017-0694-z Summary Keywords GLP-1, GLP-1RAs, T2DM, glucose, mechanism Citation He X, Zhao W, Li P, Zhang Y, Li G, Su H, Lu B and Pang Z (2025) Research progress of GLP-1RAs in the treatment of type 2 diabetes mellitus

Since this is not a "weight loss" indication, it's not excluded by the Part D statute
