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Ablation of the leptin receptor in the hypothalamic arcuate nucleus abrogates leptin-induced sympathetic activation

As the field advances, humanized preclinical systems that allow drug evaluation against human targetssuch as GCGR/GIPR/GLP1R humanized mouse modelswill play a pivotal role in bridging the gap between mechanistic discovery and clinical translation

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Consider a B12 supplement alongside tirzepatide as well, since nutrient absorption can be affected by reduced food intake

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