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The Mayo Clinic cohort: women on semaglutide plus HRT lost more weight at every timepoint (and it wasnt explained by confounders)

Call your doctor for medical advice about side effects

Ask how these drugs might interact with every medication you take, especially hormonal contraception and HRT

This worry comes from research published in the Endocrine Journal with other drugs in the same group, like semaglutide, that showed there could be an increased risk of things like deep vein thrombosis (DVT) and problems like that

In the CNS, GLP-1R is widely expressed across multiple regions implicated in energy homeostasis, reward processing, and autonomic control [16]