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You can stay at the lower dose longer if you need time to adjust

Berberine, for example, has been studied for effects on blood sugar and body weight

Blood Sugar Control (SURPASS-2) Fras JP, Davies MJ, Rosenstock J, et al

One study using galactose-decorated PLGA NPs reported significantly enhanced hepatocyte uptake of encapsulated peptides, and suggested that adapting this system for semaglutide could further improve intrahepatic exposure and anti-steatotic efficacy [253]
Jenny et al., 2002
