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Retatrutide may support fat loss as body weight decreases, but it is not simply a fat-burning injection

Mechanistic analyses from the SUMMIT trial [165] demonstrated that, compared with placebo, tirzepatide reduced blood pressure and attenuated circulatory volume expansion in obese HFpEF patients

Nonetheless, certain obese individuals at very high risk of T2D, atherosclerotic cardiovascular disease, heart failure, or renal failure could benefit from such a monotherapy

10.7554/eLife.50208 7 FengY.SuL.ZhongX.GuohongW.XiaoH.LiY.et al (2016)

In conclusion, while tirzepatide offers significant benefits, weigh these against potential side effects and contraindications