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Tan says the 12 percent increase in gout risk reported in the study is a significant increase. Its possible GLP-1s could lead to temporary changes in uric acid level because of shifting fat-muscle ratios, she says
The shorter half-life necessitates more frequent administration but allows faster dose adjustments
European Medicines Agency, 2022a
The SmPCs for all GLP-1 receptor agonists advise caution in patients with a history of pancreatitis, though they are not absolutely contraindicated
