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Interestingly, both hMSC-Ex-4 and wild-type hMSC treated with soluble Ex-4 exhibited elevated mRNA expression of GLP-1-R in a dose-dependent manner, suggesting a feedback mechanism that may potentiate hMSC responsiveness to Ex-4 [18]

Front Cell Dev Biol

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Subgroup analysis suggested benefits for patients under 60 years old, highlighting the importance of precision medicine