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C., et al., Diabetes and Cancer:A Consensus Report, Diabetes Care 33, no

*Based on STEP 1 pharmaceutical trial

[5] [6] The fundamental difference is critical: prescription medications like semaglutide 2.4 mg (Wegovy) and tirzepatide (Zepbound) produce substantial, dose-dependent increases in receptor activation with clinical trial evidence showing approximately 15% and up to 21% body weight reduction, respectively

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GLP-1RAs mitigate these adverse impacts by enhancing fatty acid oxidation via the Creb5/NR4a1 signaling axis, thereby reducing mitochondrial damage, lipid accumulation, and ATP deficiency (77, 78, 83)