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Description

Switching GLP-1 Medications If semaglutide is not providing the results you want, a provider might suggest switching to a different GLP-1 receptor agonist, such as tirzepatide (the active ingredient in Mounjaro and Zepbound)

Earlier versions of GLP-1 drugs, such as exenatide (Byetta), increased the risk for pancreatic cancer or certain types of thyroid cancer and even instances of autoimmunity

Furthermore, both in vitro and in vivo , GLP-1 has been frequently demonstrated to reduce GI muscle activity via nerve-mediated mechanisms reliant on nitric oxide (53)

The antithrombotic properties of GLP-1R agonists are complementary to those offered by platelet antagonists (aspirin, clopidogrel) and are not associated with an increased bleeding risks [99, 100]