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[DOI] [PMC free article] [PubMed] [Google Scholar] 139

Future experiments will determine whether loss of Klb expression in these neuronal populations impairs GLP-1RA weight loss across multiple high carbohydrate diets

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Increased DAG levels inhibit PKC, leading to defective activation of IRS-1/PI3K/AKT insulin signaling, downregulation of GLUT4 and forthcoming insulin resistance [170,172]
