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This can lead to big changes in their quality of life and long-lasting health benefits
[DOI] [PMC free article] [PubMed] [Google Scholar] 204.Meoni S., Macerollo A., Moro E
Patients with self-reported changes in bodyweight 5 kg within 90 days before screening and previous obesity treatment were excluded
17 35 Therefore, careful clinical monitoring is warranted, especially during the early phases of treatment
The persistent limitation is translational: rodent lipid handling differs from human physiology, and even the best diet models only partially recapitulate the slow, heterogeneous fibrotic progression seen in human MASH which is why an animal liver-fat signal is treated as hypothesis-generating rather than confirmatory
