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While standard therapeutic doses have demonstrated cardiovascular and metabolic benefits in large clinical trials, the concept of using low dose GLP-1 for inflammation remains investigational, with no established FDA indication or standardized dosing protocols

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7 For patients with type 2 diabetes who have atherosclerotic cardiovascular disease or are at high risk for it or who have kidney disease or heart failure, either a GLP-1 receptor agonist or an SGLT-2 inhibitor with demonstrated cardiovascular benefit with or without metformin is recommended, independent of the hemoglobin A1c level (level of evidence A)

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Can Microdosing GLP-1s Promote Health And Weight Loss