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Clinical trial data shows substantial AHI reductions and improved blood oxygen saturation, with apnea improvements correlating strongly with the degree of weight loss (ref)

Their food intake can be normalized by the administration of physiological doses of -estradiol but not progesterone ( Menstrual cycle and eating disorders In addition to influencing food intake in healthy states, estradiol and progesterone have also been implicated in the etiology and expression of eating disorders ( It is interesting to speculate as to whether progesterone-only contraceptives could indirectly alter insulin sensitivity ( Gonadotropins and adiposity Although, gonadotropin hormone analogs have been used clinically for decades in assisted reproductive therapies and in the treatment of various infertility disorders ( Postmenopausal women have low estradiol, elevated FSH, concomitant bone loss, and increased body fat)

Placental extracellular vesicles express active dipeptidyl peptidase IV

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That last point is where NAD becomes especially interesting