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Dizziness Weakness Drowsiness or fatigue Slow heartbeat Low blood pressure Dry mouth, skin, or eyes Headache Upset stomach Diarrhea or constipation Heart block Cold hands and feet Weight gain Less common side effects include: Depression Shortness of breath, wheezing, or trouble breathing, with people who have asthma or Raynauds syndrome facing a higher risk of these adverse effects High blood sugar (hyperglycemia) Trouble sleeping, including insomnia and nightmares Swelling of the hands or feet (edema), specifically in those who take carvedilol (Coreg) Sexual and erectile dysfunction Are There Any Risks

Skin cancers (squamous and basal cell) are the most common, followed by Post-Transplant Lymphoproliferative Disorder (PTLD), which is often driven by Epstein-Barr Virus (EBV) reactivation

Unlike nausea, which usually improves with time, reflux can linger for some people if not managed

Deadlines in March/April 2025 forced most serious parties to stop, and since September 2025 the FDA has escalated with warning letters, seizures of illegal API shipments, and coordinated actions with the Department of Justice