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Therefore, the positive cardiovascular effects of GLP-1RAs might be partially attributed to their ability to protect the kidneys, potentially restoring communication between the gut and kidneys

[DOI] [PMC free article] [PubMed] [Google Scholar] 72.Brown JC, Pederson RA

When given to DIO mice, both peptides led to significant weight reduction, improved glucose tolerance, increased energy expenditure, and reductions in plasma cholesterol and liver steatosis

Author contributions Formulation or evolution of overarching research goals and aims: DAG, ASK, DJE, JBK, PML, VMJ, JPF Data curation: JBK, DRD, PML, JPF Application of statistical and/or mathematical analyses: ARS, JBK, DRD, CB, JPF Acquisition of funding: VMJ Conducting the research and/or collecting data: DAG, ASK, AMM, CL, SWB, ARS, SH, DJE, MCG, JBK, DRD, JMD, VMJ, JMC, CB, RBR, DJL, JPF, YL, DAT, MSL Project administration: MSL, DAP Provision of study resources including animals and patients: VMJ, MSL Implementation of the relevant software or computer programs: CB Oversight and leadership of the study planning and execution: DAG, ARS, SH, DJE, JBK, PML, JMD, VMJ, CB, DJL, JPF, MSL Data verification and validation: ASK, SWB, ARS, DWP, MCG, JBK, DRD, PML, CB, JPF, DAT, MSL Preparation of the data and graphical elements of the paper: DAG, ASK, CL, DWP, DJE, JBK, DRD, PML, JMD, CB, JPF, YL, DAT Preparation of the written elements of the paper: DAG, ASK, CL, ARS, DWP, DJE, JBK, DRD, PML, JMD, JPF, YL Editing and reviewing of the paper: DAG, ASK, AMM, CL, SWB, ARS, DWP, SH, DJE, MCG, JBK, DRD

Another way in which DPP-4 inhibitors may affect bone metabolism is through a pathway linked to 25(OH)-D levels (Vitamin D, [136])