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No clinically meaningful changes were observed in ECG or safety laboratory parameters, including calcitonin

Victoza also carries a black box warning for the risk of thyroid C-cell tumors based on animal studies, and while the development of medullary thyroid carcinoma in humans remains uncertain, this risk factor continues to be part of safety discussions

The glucagon receptor component drives energy expenditure and hepatic fat mobilisation, a mechanism absent in earlier-generation incretin compounds

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