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In human narcolepsy patients there is a significant reduction in the amount of detectable orexin A and orexin B as well as an 80%100% reduction in the number of neurons that contain detectable prepro-orexin mRNA

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Neurotherapeutics 17 (1), 252268

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doi:10.1016/j.bcp.2019.03.024 Yang L, Yang J, Pan T, Zhong X
