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Si se presentaban efectos secundarios inaceptables con la dosis de 2,4 mg, el participante pudo continuar recibiendo la dosis de 1,7 mg como dosis de mantenimiento, esto ya se haba contemplado en el ensayo STEP1 (con SEMA en personas con obesidad) y lo mismo con TIRZE, bajando dosis de 15 a 10 mg, al igual que se contempl en los protocolos de los ensayos SURMOUNT anteriores

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