fda compounding semaglutide warning october 2025 issued 25 letters to telehealth companies for false and misleading claims about compounded GLP-1 products. Unlike FDA-approved drugs, these products have not been proven to be safe, effective, or of Non-Traditional Channels: The Compounded GLP-1

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The anorexigenic peptide glucagon-like peptide-1 (GLP-1) is secreted from gut enteroendocrine cells and brain preproglucagon (PPG) neurons, which respectively define the peripheral and central GLP-1 systems

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Key secondary endpoints related to physical fitness were changes from randomization to the end of treatment (weeks 052) in: (1) physical functional performance (time to ascend and descend an 11-step stairway twice)