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Weeks 13-24 (Approaching or Reaching Maintenance Dose): As you approach or reach your maintenance dose (timing varies by productWegovy typically by week 17, others on different schedules), the medication's effects stabilize

it reduces the intrinsic desire to eat, a powerful combination that forms the basis of its success as a weight-loss therapy

By stimulating insulin secretion, inhibiting glucagon release, slowing gastric emptying, and promoting satiety, GLP-1 helps maintain healthy blood sugar levels and reduces hunger

In more severe cases, especially those with clear symptoms of delayed gastric emptying, I have also introduced Gimoti - which has made a real difference for some as well

Patients who fail to respond adequately to semaglutide often respond better to tirzepatide, not because of dose differences but because the dual mechanism addresses different pathways