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Renal function should be monitored in patients with renal impairment or when experiencing severe gastrointestinal adverse effects that could lead to dehydration and acute kidney injury

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Notably, co-administration with farnesoid X receptor (FXR) agonists or peroxisome proliferator-activated receptor (PPAR) agonists may enhance lipid metabolism regulation and anti-inflammatory effects, addressing multiple pathogenic pathways simultaneously

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