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10.1200/JCO.23.02745 40 Gratacos-GinesJ.ArinoS.Sancho-BruP.BatallerR.PoseE

Unfortunately, most regain two-thirds of their lost weight within a year as well as worsening of metabolic health indicators (Mozaffarian et al., 2025

Following the readout of REDEFINE 1 in late 2024 which fell short of expectations, positive REDEFINE 4 data will become even more important for CagriSema, however, its outcome is now less certain
By having more stable glucose levels, they reduce the hormonal spikes and support metabolic health

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