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When to Call Your Clinician About Infections or Side Effects Contact your clinician for severe constipation, visible blood in stool, signs of systemic infection such as fever or chills, persistent nausea, or any genital or skin symptoms that do not improve with a short course of over-the-counter treatment

In addition to the well-known effects of GLP-1 and GLP-1 RA in improving insulin sensitivity and reducing body weight, at central levels, GLP-1 and GLP-1 RA might exert regulating effects on GhRH release, and on concomitant gonadotropin secretion, likely by activating the kisspeptin hypothalamic system, a key regulator of the pulsatile release of GnRH from GnRH neurons

However, there is not much known about DPP4 receptors so far

GLP-1 drugs may improve cerebrovascular health, which can modestly improve dementia symptoms