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It normalized markers such as malondialdehyde, nitric oxide, IL-6, and specific matrix metalloproteinases while increasing superoxide dismutase and IL-10 in the affected nerves [103]
Several novel compounds and combination therapies are undergoing clinical trials, targeting different metabolic pathways to enhance efficacy and safety

Glucagon-Like Peptide-1 Receptor Agonists and Sodium-Glucose Co-Transporter-2 Inhibitors as Combination Therapy for Type 2 Diabetes: A Systematic Review and Meta-Analysis

The weekly semaglutide injections reduced heart attack, stroke, and cardiovascular death by about 20% compared to placebo

[18] also reported that preoperative semaglutide use within 10 days of elective surgery was independently associated with increased residual gastric content, as assessed by gastric ultrasound
