stdei glp-1 mayo clinic Companion Program for GLP-1s Dustin's GLP-1 journey to health

In the 1980s, researchers at Massachusetts General Hospital discovered a hormone called GLP-1, a natural signalling molecule that tells your brain you're satisfied and should stop eating. This was interesting science, but nobody knew what to do with it

15,19,22,23,31,32,38,39,41,43 TAKE-HOME MESSAGE Lifestyle modification remains the foundation of MASH management, 9 with weight loss of at least 10% associated with fibrosis regression in most patients

Kawatani, M., Itoi, K., Talukder, A

How It Works Mimics the GLP-1 hormone to reduce appetite and increase satiety Slows gastric emptying food moves through the stomach more slowly, keeping you feeling full longer Acts on receptors in the hypothalamus to reduce hunger signaling in the brain Supports blood sugar regulation by stimulating insulin release when glucose is present Clinical Results In clinical trials, participants using Semaglutide alongside lifestyle modifications lost an average of 15% of their body weight over 68 weeks

Understanding which patients are candidates for GLP-1RAs treatment will be key, according to Lorenzo Leggio, MD, PhD, clinical director of the National Institute on Drug Abuse