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Enhanced insulin secretion and reduced glucagon levels: DPP-4 inhibitors prevent the degradation of GLP-1 and GIP, which in turn enhances the response of the pancreas's -cells to blood sugar

Clinical trial data from the STEP program showed that semaglutide 2.4mg weekly produced average weight loss of 14.9% of body weight over 68 weeks, compared to tirzepatide at 15mg which achieved approximately 22.5% in the SURMOUNT trials

10.5847/wjem.j.issn.1920-8642.2014.02.008

Moreover, the elevated markers of oxidative stress precede A deposition and NFTs, suggesting that oxidative stress is an early event in the pathogenesis of AD (67)

Women continue to dominate usage, accounting for 77% of current users compared with 23% of men