semaglutide cardiac effects Effect of on Structure and Function in Patients With Obesity-Related Heart Failure Semaglutide cardiovascular outcomes align more

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Fever exceeding 103F, chest pain, shortness of breath, or confusion warrant immediate emergency-department evaluation, regardless of semaglutide status

44 There are ongoing studies evaluating the efficacy of orforglipron on weight loss and cardiovascular outcomes (clinical trial number NCT05803421

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Finally, one can foresee a future where combination therapy becomes common: for example, a patient with diabetes and obesity might be on both a GLP-1 RA and an SGLT2 inhibitor (for complementary weight loss and cardio-renal protection, which is already done)