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The journey began in the 1980s with research on Gila monster venom, culminating in the discovery of exendin-4, a stable, effective peptide for treating diabetes, demonstrating the progression from initial discovery to blockbuster diabetes medications

Exenatide The first GLP-1RA approved for T2D is Exenatide

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These enhancements may help improve metabolic function, neurological health, and musculoskeletal strength, supporting overall wellness throughout the treatment process

Certainty of evidence All primary and secondary outcomes were judged to have high certainty of evidence across all GRADE approach [11] domains, including risk of bias (D1), inconsistency (D2), indirectness (D3), imprecision (D4), publication bias (D5)