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These complications are extensive and diverse, encompassing metabolic disorders such as type 2 diabetes 2 , dyslipidemia 3 , cardiovascular diseases 4 and an increased overall mortality risk 5

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By contrast, those on external testosterone (Group C) saw testosterone levels go up (as expected) but their LH/FSH were suppressed, and those on gonadotropins (Group A) saw some improvement in T but not as robust as liraglutides effect

In these studies, insulin was discontinued, and patients were started on liraglutide at a low dose, which was subsequently titrated based on tolerance and need

We also did not measure physical activity which is known to affect insulin sensitivity and loss of ectopic fat