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The American Medical Association classifies obesity as a disease, not simply a behavior problem, which supports the case for continuous treatment

Potential mechanisms include structural (reduction of ventricular mass and wall stress, improvement of fibrosis markers and endothelial function), dynamic (direct inhibition of myocardial Na + /H + pump, reduction of blood pressure, and improvement of the ventricular loading conditions and tubuloglomerular feedback), and energetic changes (improvement of cardiac metabolism)

[DOI] [PMC free article] [PubMed] [Google Scholar] 10.Wang K, Hu J, Luo T, et al

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Lancet 402(10401):529544 Clinical trial.gov [Home page in Internet] A study of retatrutide (LY3437943) in participants with obesity and cardiovascular disease (TRIUMPH-3)