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Recently, through the engagement of their respective receptors, studies have shown that GIP and GLP-1 have a synergistic effect on appetite and body weight when the peptides are combined in pharmacology [6, 8], but the exact mechanisms underlying the enhanced weight loss exhibited by GIPR/GLP-1R co-agonism are still to be elucidated

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In this view, people become overweight more or less because their willpower is not strong enough to avoid the temptation to overeat

This rapid degradation of GLP-1 has motivated the development of long-acting GLP-1R agonists, which are protected from DPP-IV degradation and can be used clinically (Kalra et al., 2021)