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Non-Albuminuric Diabetic Kidney Disease Phenotype DKD typically progresses through phases of glomerular hyperfiltration, microalbuminuria, overt proteinuria, and reduced eGFR, with albuminuria recognized as an early clinical marker [21,46]

P =0.022), and all-cause mortality (HR 0.64, 95% CI 0.57 0.72

however, new formulations or delivery methods, such as intrathecal or transdermal delivery systems, could vastly enhance the delivery of GLP-1RAs to sites of action in targeting the CNS and spinal cord

The mechanisms of GLP-1RAs neuroprotection may be interconnected, warranting further investigation

We also excluded patients with no diagnosis of type 2 diabetes ever before cohort entry, as well as those with diagnosed contraindications for the study drugsnamely, end stage renal disease and multiple endocrine neoplasia syndrome, assessed ever before cohort entry