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This is encouraging, but the data is observational rather than from controlled trials

That alone is a big shift

It is unclear how the duration and dosing used in this experimental system reflects the in vivo setting, though it would be of interest to benchmark the degree of desensitization/functional antagonism achieved in these studies to the GIPR antagonizing antibodies advancing through the clinic [5] or peptide antagonists reported in the literature [36]

[DOI] [PubMed] [Google Scholar] 580.Junker A.E., Gluud L.L., van Hall G., Holst J.J., Knop F.K., Vilsboll T

For some people with obesity, these medications can elicit the same weight loss as surgery, which no other medication currently can