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More importantly for muscle-focused applications, the proportion of lean mass loss to total weight loss was similar to or better than other obesity treatments, with Retatrutide demonstrating significant improvements in total body fat mass reduction compared to both placebo and dulaglutide (a single-receptor GLP-1 agonist)

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Patients should contact their GP or diabetes specialist nurse if itching persists beyond a few days, worsens progressively, or is accompanied by other concerning features

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