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Abbreviations: RCT: randomized clinical trial, NAFLD: non-alcoholic fatty liver disease, NASH: non-alcoholic steatohepatitis, BBR: berberine, ALT: alanine aminotransferase, GGT: gamma-glutamyl transferase, WC: waist circumference, BMI: body mass index, HFC: hepatic fat content, Hb A1c: hemoglobin A1c, TG: triglycerides, LDL-c: low-density lipoprotein cholesterol, 2hPG: Two-hour post-load glucose, TC: total cholesterol, AST: aspartate aminotransferase, FPG: Fasting plasma glucose, HOMA-IR: Homeostatic Model Assessment for Insulin Resistance, FINS: fasting insulin, IR: insulin resistance, HDL: high-density lipoprotein

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