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Fatigue is common in the first weeks, often related to reduced caloric intake as appetite suppression takes effect

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TL;DR: Both medications are effective for weight loss when used in recommended dosages and in combination with diet and exercise

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Tirzepatide adds GIP-receptor activation on top of GLP-1 signaling, creating synergy through proven mechanisms rather than unproven cross-therapy combinations

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Semaglutide carries a specific warning about potential worsening of diabetic retinopathy in patients with pre-existing retinopathy, particularly with rapid improvement in glucose control

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Semaglutide can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer

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