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A comprehensive literature search was conducted across the PubMed, Embase, and Google Scholar databases for peer-reviewed articles published from inception through June 15, 2026, focusing on the landmark SURPASS, SURMOUNT, and SUMMIT trial programs, relevant cardiorenal post hoc analyses, emerging body recomposition trials, and real-world cohort-switching protocols

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Notch signaling is a highly conserved cell signaling system in most multicellular organisms and plays a critical role in animal development

Theres also the issue most people are never told about: A significant part of the weight lost can be lean mass