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In one meta-analysis of RCTs, metformin worked about three times as well when starting a new antipsychotic in first-episode psychosis (about a 13-pound difference from placebo) compared with its use after chronic antipsychotic treatment (about a 4-pound difference from placebo) (De Silva VA et al, BMC Psychiatry 2016;16(1):341)

coverage wouldnt be approved for weight loss, Type 1 diabetes, diabetes prevention, or metabolic syndrome

2025 Mar;13(3):e6

Data on the number of people in the US taking glucagon-like peptide-1 medications, both to reduce obesity and to help control diabetes, show a somewhat stable trend

Patients exploring international options should be aware of tirzepatide availability in Mexico and grey market tirzepatide considerations , though domestic compounded sources typically offer better safety assurances